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Biodesign 4-Layer Tissue Graft

Tissue graft

The Biodesign 4-Layer Tissue Graft is intended for implantation to reinforce soft tissue.

It is indicated for use in chordee correction, Peyronie’s disease treatment, and urethral repair. 


Product Benefits

The Biodesign 4-Layer Tissue Graft may be implanted in all patient populations to reinforce soft tissue and can be cut to size to accommodate the patient’s anatomy.

What is the Biodesign?

Biodesign Advanced Tissue Repair products are sourced from porcine small intestinal submucosa (SIS).

Over the course of several months, the patient’s own healing mechanisms incorporate the SIS into the adjacent tissues until it can no longer be detected, resulting in new, remodelled tissue.1-4

SIS technology

SIS is derived from porcine small intestinal submucosa, a naturally occurring ECM (extracellular matrix) located between the mucosal and muscular layers of the small intestine. A complex organization of collagen and other molecules that forms a fibrous matrix, the submucosal layer of the intestine is responsible for most of its strength.

SIS provides a natural scaffold that allows the body to restore itself through site-specific tissue remodelling.

Tissue Remodelling

Tissue remodelling is a complex natural process that involves the recruitment of cells,
the renewal of tissue composition, and the reinforcement of structural tissue architecture.5

As the body heals, SIS is gradually remodelled and integrated into the body, leaving behind organized tissue that provides long-term strength.6-8


1. Mantovani F, Tondelli E, Cozzi G, et al. Reconstructive urethroplasty using porcine acellular matrix (SIS): evolution of the grafting technique and results of 10-year experience. Urologia. 2011;78(2):92-97.

2. Palminteri E Berdondini E, Fusco F, De Nunzio C, Salonia A. Long-term results of small intestinal submucosa graft in bulbar urethral reconstruction. Urology. 2012;79(3):695-701.

3. Xu YM, Fu Q, Sa YL Zhang J, Song LJ, Feng C. Outcome of small intestinal submucosa graft for repair of anterior urethral strictures. Int J Urol. 2013;20(6):622-629.

4. Konstantinidis K, Kuehhas F, Paptsoris A. The Egydio geometrical procedure for managing penile curvature using a single relaxing incision: A single-centre experience with 330 patients. Arab J Urol. 2015;13(4):287-290.

5. Turner NJ, Badylak SF. Biologic scaffolds for musculotendinous tissue repair. Eur Cell Mater. 2013;25:130-143.

6. Franklin ME Jr, Trevino JM, Portillo G, Vela I, Glass JL, Gonzalez JJ. The use of porcine small intestinal submucosa as a prosthetic material for laparoscopic hernia repair in infected and potentially contaminated field: a long term follow-up. Surg Endosc. 2008;22(9):1941-1946.

7. Stelly M, Stelly TC. Histology of CorMatrix bioscaffold 5 years after pericardial closure. Ann Thorac Surg. 2013;96(5):e127-e129.

8. Badylak S, Kokini K, Tullius B, Whitson B. Strength over time of a resorbable bioscaffold for body wall repair in a dog model. J Surg Res. 2001;99(2):282-287. 


Biodesign 4-Layer Tissue Graft is indicated for use in:

  • Chordee correction
  • Peyronie’s disease treatment
  • Urethral repair


The graft is derived from a porcine source and should not be used for patients with known sensitivity to porcine materials.

See full instructions for use, click here.


Ordering Details

Size Product code
2 x 3 cm SLH-4S-2X3-2
3.5 x 5 cm SLH-4S-3.5X5-2
4 x 7 cm SLH-4S-4X7-2
7 x 10 cm SLH-4S-7X10-2
7 x 20 cm SLH-4S-7X20-2
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